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It can be crucial to think about the flow cytometry histograms to ascertain the intensity of expression and whether or not the staining is “all, none, or partial.” The immunophenotype profile of vintage CLL is dim sIg and dim CD20; CD5 and CD23 expression (not partial expression for either) is essential.
If FCR could be the cure of decision, caution has to be taken in patients with NOTCH1 mutations, in whom rituximab seems to own small additional worth.59 Other genomic subgroups, for instance clients with BIRC3 mutations show up to derive little take advantage of CIT,111,112 but these benefits should be further more validated.
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